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URP-3518

The Research Unit (URP)-3518, University of Paris: " Clinical Research in hematology, Immunology and Transplantation " proposes:

Clinical and bioclinical research studies based on IHUB-2 THEMA and RIME (Registre des Insuffisances Médullaires) cohorts of patients with leukemia and related disorders

Partnership research projects with pharmaceutical companies and biotechs/medtechs members of the THEMA Industry Board, including proof-of-concept delivery, biomarker discovery and early clinical trial designing. These projects focus on first-in-class drug and repurposing drugs

Multi-disciplinary research in collaboration with the Human & Social Sciences Department of the Université de Paris

Hervé Dombret
Prof. Hervé Dombret

Head of Entity

Contact

Email : herve.dombret@opale.org

Hôpital Saint Louis
Institut Recherche Saint Louis (IRSL)
1, avenue Claude Vellefaux
75010 PARIS - France

Website

  • Acquired Bone Marrow Failure (BMF) syndromes
  • Acute Lymphoblastic Leukemia (ALL)

The URP-3518 focuses its research on Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), bone marrow failure syndromes, including aplastic anaemia and inherited Bone Marrow Failure (BMF) syndromes.

  • Targeted therapy
National

Research infrastructures

Cytometry

 

IRSL - Technology platform

3 missions:

  • Theoretical and practical training in the technology
  • Access to calibrated instruments (sorters and analyzers)
  • Personalized support for the design of experiments and results analysis

 

Genomics

 

IRSL - Technology platform

The main mission of the Genomics Department is to meet the needs for genomic studies related to laboratory research activities and to be open to the entire academic (INSERM, CNRS, Universities, APHP) and industrial scientific community.

 

Microscopy

 

IRSL - Technology platform

Microscopy Department provides easy access and personalized support to modern optical microscopy techniques: confocal and multiphoton microscopy, wide-field microscopy, video-microscopy (multipoint and high-throughput timelapse).

 

Animal facility

 

IRSL - Technology platform

Department of Preclinical Models is a common service whose main mission is to meet the needs for animal experimentation relating to the scientific activity of the IRSL in compliance with the national and European regulations in force on the Protection of animals used for scientific purposes.

 

Cell culture facility

 

Cell culture facility including feeder equipment for culture on mesenchymal cells layer.

 

Translational studies

The Leukemia Translational Lab (LTL) - Paris, Hôpital Saint-Louis) in collaboration with Prof. Raphaël Itzykson (GenCellDis - UMR-944).

 

Biological samples

 

Cohort

AML

ALL

MDS

MPN

 

eTHEMA leukemia cohort (AP-HP, University of Paris) A prospective non-interventional research-oriented cohort with extensive data collection in patients with AML, ALL, high-risk MDS and myelofibrosis.

Cohort

BMF

RIME bone marow failure cohorts (AP-HP, University of Paris)

A retrospective and prospective registry and biobanking of the French Reference center for acquired and constitutional aplastic anemia.

 

Cohort

Clinical data

eTHEMA leukemia cohort data.

RIME bone marow failure cohorts data.

Partnership research offers

DEVELOPMENT OF SMALL MOLECULES FOR TARGETED THERAPIES (ALL/AML)

Affiliation

Université Paris Cité