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SFCE

The SFCE is an association of health professionals (surgeons, radiotherapists, radiologists, pathologists, biologists, nurses, researchers) dedicated to improving the understanding, diagnosis, treatment and follow-up of cancers in children and adolescents, particularly childhood leukaemia. It brings together a total of over 500 members from 30 French expert centres.

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Arnaud Petit
Prof. Arnaud Petit

Head of Entity

Virginie Gandemer
Prof. Virginie Gandemer

Head of Entity

Contact

Email : arnaud.petit@aphp.fr

Hôpital Armand Trousseau
Service d’hématologie et d’oncologie pédiatrique
26, avenue Arnold Netter
75012 PARIS - France

Website

  • Myeloproliferative Neoplasms (MPN)
  • Acute Lymphoblastic Leukemia (ALL)
  • Acute Myeloid Leukemia (AML)
  • Pediatric and/or germline mutation-associated disorders

Clinical research 

  • First line therapeutic trials
  • Relapse
  • Early phases
  • Clinical-molecular correlation
  • Supportive care, etc.

Translational and basic research 

  • Pediatric leukemogenesis
  • Tumor microenvironment of pediatric leukemia
  • Drug testing
  • Biological prognosis factors
  • Genomics, etc.

 

  • Targeted therapy
  • Cell therapy
  • Immunotherapy
  • CAR-T cells
  • Chemotherapy

  • Meyran D, Arfeuille C, Chevret S, Neven Q, Caye-Eude A, Lainey E, Petit A, Rialland F, Michel G, Plantaz D, Jubert C, Theron A, Gandemer V, Ouachée-Chardin M, Paillard C, Bruno B, Buchbinder N, Pochon C, Calvo C, Fahd M, Baruchel A, Cavé H, Dalle JH, Strullu M. A predictive classifier of poor prognosis in transplanted patients with juvenile myelomonocytic leukemia: a study on behalf of the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire. Haematologica. 2024 Feb 22. doi: 10.3324/haematol.2023.284103. Epub ahead of print. PMID: 38385260.
  • Saultier P, Michel G. How I Treat long-term survivors of childhood acute leukemia. Blood. 2024 Jan 16:blood.2023019804. doi: 10.1182/blood.2023019804. Epub ahead of print. PMID: 38227937.
  • van der Sluis IM, de Lorenzo P, Kotecha RS, Attarbaschi A, Escherich G, Nysom K, Stary J, Ferster A, Brethon B, Locatelli F, Schrappe M, Scholte-van Houtem PE, Valsecchi MG, Pieters R. Blinatumomab Added to Chemotherapy in Infant Lymphoblastic Leukemia. N Engl J Med. 2023 Apr 27;388(17):1572-1581. doi: 10.1056/NEJMoa2214171. PMID: 37099340.
  • Arend von Stackelberg, Jean-Pierre Bourquin, Martin Zimmermann, Tamas Revesz, Andishe Attarbaschi, Alina Ferster, Lucie Sramkova, Thomas Leth Frandsen, Päivi Maria Lähteenmäki, Ronit Elhasid, Hidemi Toyoda, Peter M. Hoogerbrugge, Inga M. Johannsdottir, Ximo Duarte, Denise Bonney, Vaskar Saha, Ingo G. Steffen, Andrej Lissat, Christiane Chen-Santel, Cornelia Eckert, Andre Baruchel, Arnaud Petit, Hélène Cavé, Carmelo Rizzari, Giovanni Cazzaniga, Luciana Vinti, Pierre Rohrlich, Franco Locatelli; ALL-REZ BFM 2002 Is Associated with Improved Outcome as Compared to ALL-R3 Strategy in Children with Standard Risk Isolated CNS Relapse of Acute Lymphoblastic Leukemia, while Maintaining Comparable Efficacy in Patients with Bone Marrow Relapse. Results of the Multi-National, Multi-Center Trial IntReALL SR 2010. Blood 2022; 140 (Supplement 1): 3247–3249. doi.org/10.1182/blood-2022-166234
  • Dourthe ME, Rabian F, Yakouben K, Chevillon F, Cabannes-Hamy A, Méchinaud F, Grain A, Chaillou D, Rahal I, Caillat-Zucman S, Lesprit E, Naudin J, Roupret-Serzec J, Parquet N, Brignier A, Guérin-El Khourouj V, Lainey E, Caye-Eude A, Cavé H, Clappier E, Mathis S, Azoulay E, Dalle JH, Dhédin N, Madelaine I, Larghero J, Boissel N, Baruchel A. Determinants of CD19-positive vs CD19-negative relapse after tisagenlecleucel for B-cell acute lymphoblastic leukemia. Leukemia. 2021 Dec;35(12):3383-3393. doi: 10.1038/s41375-021-01281-7. Epub 2021 May 17. PMID: 34002027. 
  • Niswander LM, Loftus JP, Lainey É, Caye-Eude A, Pondrom M, Hottman DA, Iacobucci I, Mullighan CG, Jain N, Konopleva M, Cavé H, Baruchel A, Rohrlich PS*, Tasian SK*. Therapeutic potential of ruxolitinib and ponatinib in patients with EPOR-rearranged Philadelphia chromosome-like acute lymphoblastic leukemia. Haematologica. 2021 Oct 1;106(10):2763-2767. doi: 10.3324/haematol.2021.278697
  • Andrea Biondi*, Virginie Gandemer*, Paola De Lorenzo, Gunnar Cario, Myriam Campbell, Anders Castor, Rob Pieters, André Baruchel, Ajay Vora, Veronica Leoni, Jan Stary, Gabriele Escherich, Chi-Kong Li, Giovanni Cazzaniga, Hélène Cavé, Jutta Bradtke, Valentino Conter, Vaskar Saha, Martin Schrappe, Maria Grazia Valsecchi. Imatinib treatment of paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (EsPhALL2010): a prospective, intergroup, open-label, single-arm clinical trial. Lancet Haematol 2018 Dec; 5 e641-52. PMID: 30501871
  • Oudin C, Berbis J, Bertrand Y, Vercasson C, Thomas F, Chastagner P, Ducassou S, Kanold J, Tabone MD, Paillard C, Poirée M, Plantaz D, Dalle JH, Gandemer V, Thouvenin S, Sirvent N, Saultier P, Béliard S, Leverger G, Baruchel A, Auquier P, Pannier B, Michel G. Prevalence and characteristics of metabolic syndrome in adults from the French childhood leukemia survivors' cohort: a comparison with controls from the French population. Haematologica. 2018 Apr;103(4):645-654. doi: 10.3324/haematol.2017.176123. Epub 2018 Jan 19. PMID: 29351982; PMCID: PMC5865433.
  • Boissel N, Auclerc MF, Lhéritier V, Perel Y, Thomas X, Leblanc T, Rousselot P, Cayuela JM, Gabert J, Fegueux N, Piguet C, Huguet-Rigal F, Berthou C, Boiron JM, Pautas C, Michel G, Fière D, Leverger G, Dombret H, Baruchel A. Should adolescents with acute lymphoblastic leukemia be treated as old children or young adults? Comparison of the French FRALLE-93 and LALA-94 trials. J Clin Oncol. 2003 Mar 1;21(5):774-80. doi: 10.1200/JCO.2003.02.053. Epub 2003 Mar 1. PMID: 12610173.

Research infrastructures

LEA Platform for long-term follow-up of patients cured of acute leukemia.

International Chronic Myeloid Leukemia Pediatric Study (ICMLPed) - an international, retrospective, prospective, non-therapeutic, non-interventional study.

Biological samples  

Various sources

AML

Biobank of pediatric acute myeloid leukemias: Pr Hélène Lapillonne, Hôpital Armand Trousseau, AP-HP, Paris

 

Clinical trial

ALL

InteReALL Biobank (Acute Lymphoblastic Leukemia in Relapse) (part of France): Robert Debré Hospital, AP-HP, Paris

 
  EsPhALL Biobank (Ph1-ALL) (part of France): Hôpital Robert Debré, AP-HP, Paris

Various sources

Clinical data

DOREMy (database of clinical and biological data for research into paediatric myeloid pathologies and their predisposing syndromes), a clinical and biological database for pediatric acute myeloid.

 
 

LEA cohort for long-term follow-up of patients cured of acute leukemia

 

Registry/observatory

Clinical data

I-CML Ped Study (international CML database)

Partnership research offers

NATIONAL CLINICAL RESEARCH NETWORK FOR THE DESIGN AND CONDUCT OF PHASE I-IV INTERVENTIONAL AND NON-INTERVENTIONAL CLINICAL TRIALS IN CHILDHOOD AND ADOLESCENT LEUKEMIA (AML/ALL/MPS/MDS)

Partners

Academics

Affiliation

Société Française de Lutte contre les Cancers et Leucémies de l'Enfant et de l'Adolescent (SFCE)