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CRSA (UMR-938)

The UMR-938 (Saint-Antoine research center, CRSA) houses the "Hematopoietic and leukemic development" team led by Prof. François Delhommeau. This team focuses on the following research themes: myeloid leukemia, hematopoiesis, erythropoiesis.

Image CRSA (UMR-938)
François Delhommeau
Prof. François Delhommeau

Head of Entity

Contact

Email : francois.delhommeau@aphp.fr

Equipe Delhommeau,
Centre de Recherche Saint-Antoine (CRSA)
Faculté de Médecine Sorbonne Université, Site Saint-Antoine
21, rue de Chaligny
75012 PARIS - France

Website

  • Myeloproliferative Neoplasms (MPN)
  • Inherited Bone Marrow Failure (BMF) syndromes
  • Acute Myeloid Leukemia (AML)
  • Myelodysplastic Syndromes (MDS)
  • Leukemia predisposition syndromes

  • Acute Myeloid Leukemia
  • Chronic myeloid malignancies
  • Congenital neutropenia
  • Histiocytosis
  • Red blood cell production
  • Participation to the development of new strategies for cytomorphologic diagnosis and stratification of leukemia
  • Production of hematopoietic stem cells from induced-pluripotent stem (iPS) cells

  • Targeted therapy
  • Cell therapy
  • Alternative therapy

Scientific

  • Clonal architecture of AML
  • Description of the bone marrow cytokine pattern in AML

Medical

  • Development of clone-specific measurement of residual disease in AML  
  • Description of somatic genetic rescue processes involving TP53 mutations in Shwachman Diamond Syndrome  

  • Hirsch P, Tang R, Abermil N, Flandrin P, Moatti H, Favale F, Suner L, Lorre F, Marzac C, Fava F, Mamez AC, Lapusan S, Isnard F, Mohty M, Legrand O, Douay L, Bilhou-Nabera C, Delhommeau F. Precision and prognostic value of clone-specific minimal residual disease in acute myeloid leukemia. Haematologica. 2017 Jul;102(7):1227-1237. doi: 10.3324/haematol.2016.159681.
  • Guermouche, H.; Ravalet, N.; Gallay, N.; Deswarte, C.; Foucault, A.; Beaud, J.; Rault, E.; Saindoy, E.; Lachot, S.; Martignoles, J.-A.; Gissot, V.; Suner, L.; Gyan, E.; Delhommeau, F.; Herault, O.; Hirsch, P. High Prevalence of Clonal Hematopoiesis in the Blood and Bone Marrow of Healthy Volunteers. Blood Adv 2020, 4 (15), 3550–3557. https://doi.org/10.1182/bloodadvances.2020001582.
  • Sourdeau, E.; Suner, L.; Memoli, M.; Genthon, A.; Feger, F.; Soret, L.; Abermil, N.; Heuberger, L.; Bilhou-Nabera, C.; Guermouche, H.; Favale, F.; Lapusan, S.; Chaquin, M.; Hirschauer, C.; Mohty, M.; Legrand, O.; Delhommeau, F.; Hirsch, P. Clinical and Biological Impact of ATP-Binding Cassette Transporter Activity in Adult Acute Myeloid Leukemia. haematol 2022, 1;108(1):61-68. https://doi.org/10.3324/haematol.2022.280676.
  • Parmentier, R.; Racine, L.; Moussy, A.; Chantalat, S.; Sudharshan, R.; Papili Gao, N.; Stockholm, D.; Corre, G.; Fourel, G.; Deleuze, J.-F.; Gunawan, R.; Paldi, A. Global Genome Decompaction Leads to Stochastic Activation of Gene Expression as a First Step toward Fate Commitment in Human Hematopoietic Cells. PLoS Biol 2022, 20 (10), e3001849. https://doi.org/10.1371/journal.pbio.3001849.
  • Ravalet N, Guermouche H, Hirsch P, Picou F, Foucault A, Gallay N, Martignoles JA, Beaud J, Suner L, Deswarte C, Lachot S, Rault E, Largeaud L, Gissot V, Béné MC, Gyan E, Delhommeau F, Herault O. Modulation of bone marrow and peripheral blood cytokine levels by age and clonal hematopoiesis in healthy individuals. Clin Immunol. 2023 Oct;255:109730. doi: 10.1016/j.clim.2023.109730.

Research infrastructures

Microscopy

CRSA platform - Image analysis: CISA

 

Cytometry

CRSA platform  - Cytometry: CISA

 

Animal facility

CRSA platform  - Animal facility: PHEA

 

Mass spectrometry

CRSA platform - Mass spectrometry

 

Histomorphology

CRSA platform - Histomorphology

 
Category Models Pathology Specification Sample type Number of models Genetics characterization
In vitro Transduced human primary cells TET2 Clonal Hematopoiesis - - - All
In vitro Transduced human primary cells DNMT3A Clonal Hematopoiesis - - - All
In vitro Transduced human primary cells TP53 Clonal Hematopoiesis - - - All
In vitro Human primary cells DNMT3A AML - Relapse - All
In vitro Human primary cells DNMT3A AML - Diagnosis - All
In vitro Human primary cells TP53 AML - Relapse - All
In vitro Human primary cells TP53 AML - Diagnosis - All
In vitro Human primary cells TET2 AML - Relapse - All
In vitro Human primary cells TET2 AML - Diagnosis - All
In vitro Human primary cells Shwachman Diamond - Follow-up - -

Partnership research offers

STUDIES OF THE MECHANISM OF HEMATOPOIETIC STEM CELL TRANSFORMATION IN ACUTE MYELOID LEUKEMIA AND CLONAL SELECTION MODELS

ARTIFICIAL INTELLIGENCE-AUGMENTED CELLULAR IMAGING IN ACUTE MYELOID LEUKEMIA (DIAGNOSIS, PROGNOSIS, STRATIFICATION)

Partners

Academics

Affiliation

Inserm Sorbonne Université