• Preclinical development
  • AML
  • MDS
  • CMML
  • Targeted therapy
  • Immunotherapy
  • Chemotherapy
  • Preclinical research (TRL 4-5)

Identification or validation of therapeutic targets in cellulo using click chemistry technology, to develop new diagnostic methods or targeted therapies.

The Click chemistry technology, which consists in precipitating a molecule with its target after their interaction in cellulo, offers numerous opportunities in biological and medical research. Applied in the field of hematological malignancies, it is used to identify protein targets in their cellular environment.

Description

Scope of research activities

Preclinical research to study protein targets in leukemia cells.

  • Demonstration of mechanism of action 

Conduct of studies

Steps:

  • Analysis of study strategy
  • Study design and feasibility
  • Drafting of study plans
  • Organization, implementation and conduct of studies
  • Analysis and communication of results

Research infrastructure

Experimental and analytical platforms:

  • Click-chemistry in cellulo
  • Western blot (1D, 2D)
  • Mass spectrometry

Models: (human or murine)

  • Primary cells  
  • Tumor cells
  • Cell lines

Technical personnel:

  • 1 engineer 

Specifications

The platform

Identification of therapeutic targets in cellulo using click chemistry technology.

The studies

Study steps: 

  • In cellulo click chemistry
  • Western blot (1D, 2D)
  • Mass spectrometry

Identification and validation of therapeutic targets:

  • Identification of targets of a compound under therapeutic development
  • Validation of targets of a compound already clinically validated 

Terms

OPALE entity

C3M (UMR-1065)

C3M (UMR-1065)
Guillaume Robert
Dr. Guillaume Robert
Team leader

Contact

Sandrine Palcy Dr. Sandrine Palcy
Business Development Director

Other offers

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